3,4,5-TRIFLUOROBENZYL BROMIDE synthesis
- Product Name:3,4,5-TRIFLUOROBENZYL BROMIDE
- CAS Number:220141-72-0
- Molecular formula:C7H4BrF3
- Molecular Weight:225.01
The 3,4,5-trifluorobenzyl bromide can be obtained from 3,4,5-trifluorobenzaldehyde by first preparing (3,4,5-trifluorophenyl)methanol as raw material and then brominating to obtain 3,4,5-trifluorobenzyl bromide.
Step A: (3,4,5-Trifluorophenyl)me
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Yield:-
Reaction Conditions:
with dibromo sulfoxide in dichloromethane at 20; for 16 h;
Steps:
62.B
To a solution of the (3,4,5-Trifluorophenyl)methanol (40 mmol) in CH2Cl2 (150 ml), a solution of thionyl bromide (6.16 ml, 80 mmol) in CH2Cl2 (50 ml) was added slowly. The reaction mixture stirred at room temperature for 16h and poured into ice-water (200 ml). The organic layer was separated and washed with saturated NaHCO3 (2x200 ml), water (200 ml), dried (MgSO4) and evaporated to obtain the corresponding bromo compound as a pale yellow oil in quantitative yield. The crude product was carried forward for the next reaction without further purification.
References:
VALEANT RESEARCH & DEVELOPMENT WO2007/14011, 2007, A2 Location in patent:Page/Page column 91