3-Aminopyrazole synthesis
- Product Name:3-Aminopyrazole
- CAS Number:1820-80-0
- Molecular formula:C3H5N3
- Molecular Weight:83.09
6162-76-1
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1820-80-0
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Yield:-
Reaction Conditions:
with hydrazine in ethanol at 60; for 24 h;
Steps:
Step ii:
General procedure: A solution of 50 mg (0.34 mmol) of 3-oxo-3-phenylpropanenitrile and 11.6 mg (0.36 mmol) of hydrazine and 0.024 mL of acetic acid (0.37 mmol) in 3 mL of anhydrous ethanol was heated at 60° C for 24 hr. The mixture was cooled to ambient temperature and the solvent removed in vacuo. The residue was taken up in ethyl acetate, washed with saturated sodium bicarbonate. The organic layer was washed with brine and dried over MgSO4, filtered and evaporated. The solid residue waswashedwithethyl ether and dried in vacuo to give 45 mg (82%) of 3-phenyl-1H-pyrazol-5-amine.
References:
Rana, Sandeep;Sonawane, Yogesh A.;Taylor, Margaret A.;Kizhake, Smitha;Zahid, Muhammad;Natarajan, Amarnath [Bioorganic and Medicinal Chemistry Letters,2018,vol. 28,# 23-24,p. 3736 - 3740] Location in patent:supporting information
26621-44-3
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1820-80-0
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41680-34-6
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1820-80-0
471 suppliers
$5.00/5g