Yield:-

Reaction Conditions:

with hydroxylamine hydrochloride;triethylamine in ethanol at 75; for 24 h;

Steps:

21.1

Step 1: To 3-bromo-4-fluorobenzonitrile (10 g, 50 mmol) in EtOH (125 ml) add Et₃N (16.1 ml, 115 mmol) and add hydroxylamine hydrochloride (7.64 g, 110 mmol). Heat to 75° C. and stir 24 h. Allow to cool, concentrate, and partition with EtOAc and water. Dry (MgSO₄) and concentrate to obtain the amide oxime as a white solid.

References:

US2007/66620,2007,A1 Location in patent:Page/Page column 18