3-Bromo-4-hydroxypyridine synthesis
- Product Name:3-Bromo-4-hydroxypyridine
- CAS Number:36953-41-0
- Molecular formula:C5H4BrNO
- Molecular Weight:174
13534-98-0
285 suppliers
$6.00/250mg
36953-41-0
164 suppliers
$35.00/1g
Yield:36953-41-0 66.2%
Reaction Conditions:
with sulfuric acid;sodium nitrite in water at 0 - 95;
Steps:
5.1.2 Preparation of 3-bromo-4-hydroxypyridine (2)
Concentrated sulfuric acid (85.0mL) and the 3-bromo-4-aminopyridine (113.0g, 0.65mol) were added successively to the distilled water (550.0mL) at 0°C, and then NaNO2 (63.1g, 0.91mol) aqueous solution (130.0mL) was added drop-wise to maintain the temperature between 0 and 5°C. After stirring at r. t. for 1h, the reaction mixture was heated at 95°C for a further 0.5h. Upon cooling to below 0°C, the mixture was alkalized to pH 6 with saturated sodium hydroxide solution, washed with ethyl acetate (200mL×3) and brine (200mL), dried over anhydrous Na2SO4, filtered and concentrated to yield the title compound 2 as a yellow solid (75.1g, 66.2%). MS (ESI) m/z: 173.9 [M+H]+
References:
Zhao, Sijia;Zhang, Yu;Zhou, Hongyang;Xi, Shuancheng;Zou, Bin;Bao, Guanglong;Wang, Limei;Wang, Jiao;Zeng, Tianfang;Gong, Ping;Zhai, Xin [European Journal of Medicinal Chemistry,2016,vol. 120,p. 37 - 50]
25813-25-6
85 suppliers
$29.00/1g
36953-41-0
164 suppliers
$35.00/1g
626-64-2
531 suppliers
$6.00/5g
36953-41-0
164 suppliers
$35.00/1g
25813-25-6
85 suppliers
$29.00/1g
1124-33-0
338 suppliers
$10.00/1g
36953-41-0
164 suppliers
$35.00/1g
626-64-2
531 suppliers
$6.00/5g
36953-41-0
164 suppliers
$35.00/1g