3-Chloro-4-fluoronitrobenzene synthesis
- Product Name:3-Chloro-4-fluoronitrobenzene
- CAS Number:350-30-1
- Molecular formula:C6H3ClFNO2
- Molecular Weight:175.54
350-46-9
530 suppliers
$10.60/1gm:
350-30-1
333 suppliers
$14.00/1g
Yield:350-30-1 75%
Reaction Conditions:
with N-chloro-succinimide;sulfuric acid;iodine;nitric acid at 20; for 2 h;Reagent/catalyst;Concentration;
Steps:
6 Example 6
35 mmol (5 g) of p-fluoronitrobenzene was suspended in 15 mL of a 20% solution of nitric acid and sulfuric acid (1: 1) by volume,In the presence of iodine (0.5 g) catalysis, 42 mmol (5.6 g) of N-chlorosuccinimide,The reaction was completed at room temperature for 2 hours. The reaction was completed, diluted with 30 mL of water, extracted with ethyl acetate (3 × 30 mL), washed with 20% sodium thiosulfate (2 × 20 mL) and 20 mL of brine, dried over anhydrous sodium sulfate, After evaporation to give the crude 3-chloro-4-fluoronitrobenzene, the crude product was recrystallized from methanol to give pure 3-chloro-4-fluoronitrobenzene 4.6g, a yield of 75%.
References:
Shandong Youbang Biochemical Technology Co., Ltd.;Wang Lei;Yang Rui;Li Juan;Han Meng;Wu Feilong;Lai Xinsheng;Lai Chao;Lai Ziteng CN106631811, 2017, A Location in patent:Paragraph 0012; 0013; 0014; 0015; 0016; 0017; 0018
99-54-7
46 suppliers
$13.00/25g
350-30-1
333 suppliers
$14.00/1g
126-33-0
547 suppliers
$5.00/25g
99-54-7
46 suppliers
$13.00/25g
5137-55-3
454 suppliers
$5.00/10g
350-30-1
333 suppliers
$14.00/1g
