3-Cyclopropylbenzoic acid synthesis
- Product Name:3-Cyclopropylbenzoic acid
- CAS Number:1129-06-2
- Molecular formula:C10H10O2
- Molecular Weight:162.19
148438-02-2
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1129-06-2
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$122.00/250mg
Yield:1129-06-2 76%
Reaction Conditions:
Stage #1:methyl 3-cyclopropylbenzoate with methanol;lithium hydroxide;water for 3 h;
Stage #2: with hydrogenchloride in methanol;water; pH=~ 3
Steps:
32
To a solution of methyl-3-cyclopropylbenzoate (0.275 g, 1.56 mmol) in MeOH (10 ml) and H2O (1 ml) was added LiOH-H2O (0.131 g, 3.00 mmol). After 3 hours the pH was adjusted to ~3 by the addition of 3N HCl, and the aqueous phase extracted with EtOAc (3 X
References:
ASTRAZENECA AB;ASTRAZENECA UK LIMITED WO2007/71955, 2007, A1 Location in patent:Page/Page column 55-56
124-38-9
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1798-85-2
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1129-06-2
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$122.00/250mg
618-89-3
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411235-57-9
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1129-06-2
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$122.00/250mg
1798-85-2
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544-92-3
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1129-06-2
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52780-14-0
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1129-06-2
67 suppliers
$122.00/250mg