3-FLUOROBENZYLOXYBENZENE synthesis
- Product Name:3-FLUOROBENZYLOXYBENZENE
- CAS Number:72216-35-4
- Molecular formula:C13H11FO
- Molecular Weight:202.22
372-20-3
396 suppliers
$7.00/5g
100-39-0
431 suppliers
$10.00/10 g
72216-35-4
53 suppliers
$35.00/250 mg
Yield:72216-35-4 87%
Reaction Conditions:
Stage #1:3-fluorophenol;benzyl bromide with potassium carbonate in DMF (N,N-dimethyl-formamide) at 20; for 5 h;
Stage #2: with hydrogenchloride in DMF (N,N-dimethyl-formamide);water
Steps:
30.A
Preparation 30; 4-hydroxy-2-fluoro-dihydro-ethyl cinnamate; Step A; 3-fluorobenzyhenol; Benzyl bromide (2.9 mL, 24. 08 mmol) is added to a suspension of 3-fluorophenol (3.0 g, 26.76 mmol) and K2CO3 (4.0 g, 28.94 mmol) in DMF (30 mL), and the mixture is stirred at r. t. for 5 h. It is acidified with diluted HC1 (1M) and partitioned between EtOAc and H20. The organic layer is dried, filtered and concentrated, and the product is purified by flash chromatography on Si02 (3% EtOAc/hexanes) to afford 4.7 g of the title compound (87%, colorless oil).
References:
ELI LILLY AND COMPANY WO2005/66136, 2005, A1 Location in patent:Page/Page column 68
372-18-9
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100-51-6
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$5.00/100g
72216-35-4
53 suppliers
$35.00/250 mg
53087-13-1
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$11.00/5g
946-80-5
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$10.00/1g
72216-35-4
53 suppliers
$35.00/250 mg
100-39-0
431 suppliers
$10.00/10 g
147460-41-1
280 suppliers
$5.00/1g
202857-88-3
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$67.00/500mg
72216-35-4
53 suppliers
$35.00/250 mg
372-20-3
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$7.00/5g
100-44-7
643 suppliers
$13.50/250G
72216-35-4
53 suppliers
$35.00/250 mg