3-Fluorophenol synthesis
- Product Name:3-Fluorophenol
- CAS Number:372-20-3
- Molecular formula:C6H5FO
- Molecular Weight:112.1
1121-86-4
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$8.00/5g
372-20-3
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$7.00/5g
Yield:372-20-3 96%
Reaction Conditions:
with Hexadecachlor-kupfer-phthalocyanin;sodium hydroxide in lithium hydroxide monohydrate;dimethyl sulfoxide at 110; for 6 h;Inert atmosphere;
Steps:
8 Example 8
CuPcCl16(22.4 mg) and NaOH (320 mg) were added to a Shrek reaction tube with a magnetic stir bar.The reaction vessel was evacuated and backfilled with argon three times, then DMSO (5.0 mL) and water (5.0 mL) were added under an argon atmosphere in a ratio of 1:1, and m-fluoroiodobenzene (952 mg) was added in a molar ratio of 1 : 0.005: 2, the reaction mixture was heated at 110 °C for 6 hours with stirring speed 100-200 rmp.After the reaction was completed, it was cooled to room temperature, diluted with saturated brine, adjusted to pH 6-7 with dilute HCl, then extracted with ethyl acetate three times and washed with saturated brine.The combined organic phases were dried over anhydrous Na2SO4andconcentratedinvacuo.The residue was purified by flash column chromatography (mobile phase was petroleum ether/ethyl acetate (vv: 40-5:1)) to obtain the target product.The target product is a white-brown liquid with a yield of 96%.
References:
CN114805031,2022,A Location in patent:Paragraph 0059-0062
768-35-4
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372-20-3
394 suppliers
$7.00/5g
1583-58-0
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$6.00/5g
372-20-3
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$7.00/5g
114635-97-1
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372-20-3
394 suppliers
$7.00/5g
372-19-0
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$10.00/1g
372-20-3
394 suppliers
$7.00/5g