3-Hydroxy-1-phenyl-1,2,4-triazole synthesis
- Product Name:3-Hydroxy-1-phenyl-1,2,4-triazole
- CAS Number:4231-68-9
- Molecular formula:C8H7N3O
- Molecular Weight:161.16
100-63-0
375 suppliers
$10.00/1g
4231-68-9
108 suppliers
$58.00/1g
Yield:-
Reaction Conditions:
with formic acid;sulfuric acid;urea in 5,5-dimethyl-1,3-cyclohexadiene
Steps:
35 1-Phenyl-3-hydroxy-1,2,4-triazole
EXAMPLE 35 (Single-pot process) 1-Phenyl-3-hydroxy-1,2,4-triazole 108 g (1 mol) of phenyl hydrazine and 60 g (1 mol) of urea were suspended in 500 ml of xylene and 111 g (1 mol) of concentrated sulfuric acid were added while stirring vigorously. The mixture was heated for 2.5 hours at 135° C. and water formed was separated via a water separator. After cooling to 90° C. 135.2 g (2.5 mols) of 85% formic acid and 25 g (0.25 mol) of concentrated sulfuric acid were added successively and the mixture was further heated for 6 hours at 95° C. After cooling, the product was filtered off, washed thoroughly with water until free from acid and dried in vacuo at 100° C. There were obtained 124.6 g (77.5% of the theory) of 1-phenyl-3-hydroxy-1,2,4-triazole having a melting point of 281°-282° C.
References:
Hoechst Aktiengesellschaft US4467098, 1984, A
64-18-6
1151 suppliers
$22.12/250ML
100-63-0
375 suppliers
$10.00/1g
57-13-6
814 suppliers
$5.00/5g
4231-68-9
108 suppliers
$58.00/1g
103-03-7
131 suppliers
$40.00/25g
4231-68-9
108 suppliers
$58.00/1g
64-18-6
1151 suppliers
$22.12/250ML
103-03-7
131 suppliers
$40.00/25g
4231-68-9
108 suppliers
$58.00/1g
122-51-0
516 suppliers
$10.00/5ml
103-03-7
131 suppliers
$40.00/25g
4231-68-9
108 suppliers
$58.00/1g