3-Hydroxy-2-naphthoyl-ortho-phenetidide synthesis
- Product Name:3-Hydroxy-2-naphthoyl-ortho-phenetidide
- CAS Number:92-74-0
- Molecular formula:C19H17NO3
- Molecular Weight:307.34
94-70-2
187 suppliers
$21.00/25g
92-70-6
445 suppliers
$10.00/10g
92-74-0
134 suppliers
$133.00/250mg
Yield: 61%
Reaction Conditions:
with phosphorus trichloride in chlorobenzene at 130; for 0.25 h;
Steps:
3.2.2. General Procedure for the Synthesis of Carboxamide Derivatives 2-8c
General procedure: 3-Hydroxynaphthalene-2-carboxylic acid (5.3 mmol) and the appropriate alkoxyaniline (5.3 mmol) were suspended in dry chlorobenzene (25 mL). Phosphorous trichloride (0.23 mL, 2.7 mmol) was added dropwise, and the reacting mixture was heated in the microwave reactor at maximal allowed power 500 W and 130°C, using infrared flask-surface control of temperature, for 15 min. The solvent was evaporated under reduced pressure and the solid residue washed with 50 mL of 2 M HCl. The crude product was recrystallized from aqueous ethanol.
References:
Gonec, Tomas;Zadrazilova, Iveta;Nevin, Eoghan;Kauerova, Tereza;Pesko, Matus;Kos, Jiri;Oravec, Michal;Kollar, Peter;Coffey, Aidan;O'Mahony, Jim;Cizek, Alois;Kralova, Katarina;Jampilek, Josef [Molecules,2015,vol. 20,# 6,p. 9767 - 9787]
95-55-6
553 suppliers
$5.00/5 g
92-74-0
134 suppliers
$133.00/250mg
92-70-6
445 suppliers
$10.00/10g
92-74-0
134 suppliers
$133.00/250mg