ChemicalBook CAS DataBase List 3-Hydroxy-2-nitropyridine

3-Hydroxy-2-nitropyridine synthesis

2synthesis methods

Product Name:3-Hydroxy-2-nitropyridine
CAS Number:15128-82-2
Molecular formula:C5H4N2O3
Molecular Weight:140.1

Synthesis of 3-hydroxy-2-nitropyridine: add 10g of 3-hydroxypyridine, 80ml of ethyl acetate, 4.2g of KNO3 and 21ml of acetic anhydride into a 250mL three-necked flask, and heat at 45°C with magnetic stirring After the reaction is completed, it is cooled to room temperature, filtered with suction, washed with a small amount of ethyl acetate for 1 to 2 times, the filtrate is taken to adjust the pH to neutrality with saturated NaOH solution, and extracted with ethyl acetate for 3 to 4 times. , take the extract and add activated carbon and heat under reflux for 1 hour, cool and filter, take the filtrate, dry with anhydrous magnesium sulfate, filter, concentrate on a rotary evaporator, and dry in a drying oven. 11.9 g of 3-hydroxy-2-nitropyridine was obtained with a yield of 81%.

109-00-2
604 suppliers
$10.00/10g

15128-82-2
461 suppliers
$10.00/10g

Yield:15128-82-2 60%

Reaction Conditions:

with aluminium trinitrate in acetonitrile at 50;regioselective reaction;

References:

Juárez-Ornelas, Kevin A.;Jiménez-Halla, J. Oscar C.;Kato, Terumasa;Solorio-Alvarado, César R.;Maruoka, Keiji [Organic Letters,2019,vol. 21,# 5,p. 1315 - 1319] Location in patent:supporting information

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74037-50-6
81 suppliers
$19.00/250mg

15128-82-2
461 suppliers
$10.00/10g

References

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3-Hydroxy-2-nitropyridine synthesis

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