4-Hydroxy-3-nitropyridine synthesis
- Product Name:4-Hydroxy-3-nitropyridine
- CAS Number:5435-54-1
- Molecular formula:C5H4N2O3
- Molecular Weight:140.1
31872-62-5
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5435-54-1
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Yield:5435-54-1 89%
Reaction Conditions:
Stage #1:4-methoxy-3-nitro-pyridine with water;hydrogen bromide at 100; for 16 h;
Stage #2: with sodium hydroxide;water at 5; for 0.166667 h;
Steps:
A.1
Step 1: 3-Nitro-pyridin-4-ol 4-Methoxy-3-nitropyridine (25.0 g, 162 mmol) in 220 ml conc. hydrobromic acid (48%) was refluxed at 100° C. for 16 hrs. The reaction mixture was cooled, poured into ice water and neutralized with 155 ml conc. NaOH (32%). The suspension was stirred for 10 min. at 5° C. and filtered. The solid was washed with water and dried at 50° C. and <30 mbar for 1 hour. The desired product was obtained as a light yellow solid (20.2 g, 89%).
References:
Jaeschke, Georg;Kolczewski, Sabine;Porter, Richard H.P.;Schnider, Patrick;Vieira, Eric US2007/105891, 2007, A1 Location in patent:Page/Page column 9-10
626-64-2
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5435-54-1
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