ChemicalBook CAS DataBase List 3-Hydroxy-N-methyl-3-phenyl-propylamine

3-Hydroxy-N-methyl-3-phenyl-propylamine synthesis

12synthesis methods

Product Name:3-Hydroxy-N-methyl-3-phenyl-propylamine
CAS Number:42142-52-9
Molecular formula:C10H15NO
Molecular Weight:165.23

3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.

2538-50-3 Synthesis

3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

2538-50-3
116 suppliers
$24.00/100mg

42142-52-9
365 suppliers
$11.00/25g

Yield:42142-52-9 90%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 20; for 1 h;

Steps:

1
The 2a (0.5mmol) was dissolved in 0.5mL of methanol,At room temperature was slowly added NaBH 4 (2.0mmol),Mixture was stirred at room temperature 1h.Added 2mL saturated NH 4Cl solution.The solvent was removed by distillation under reduced pressure.The residue was added 5mLNaOH (1N),With 5mLCH 2Cl 2 and extracted four times.The organic phase was collected and dried over anhydrous sodium sulfate,And concentrated to give the crude product.The crude product after column chromatography product 2b.Yield: 90%.

References:

YUFEI;YU, FEI CN103992236, 2016, B Location in patent:Paragraph 0051;0054; 0055

FullText

18776-12-0
186 suppliers
$11.00/1 / G

74-89-5 Synthesis

74-89-5
0 suppliers
$13.44/25ML

42142-52-9
365 suppliers
$11.00/25g

References

877-50-9 Synthesis

877-50-9
5 suppliers
inquiry

42142-52-9
365 suppliers
$11.00/25g

References

5409-62-1 Synthesis

3-(N-Benzyl-N-methylamino)propiophenone hydrochloride

5409-62-1
32 suppliers
inquiry

42142-52-9
365 suppliers
$11.00/25g

References

1-Propanone, 3-[methyl(phenylmethyl)amino]-1-phenyl-

21970-65-0
28 suppliers
inquiry

42142-52-9
365 suppliers
$11.00/25g

References

3-Hydroxy-N-methyl-3-phenyl-propylamine Related Search:

1-Phenyl-1-propanol Methylparaben Benzyl alcohol PHENYL VALERATE 1-Propanol Ethyl acetate Benzyl benzoate Ethanol Meglumine ent S-(+)-Atomoxetine Hydrochloride

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3-Hydroxy-N-methyl-3-phenyl-propylamine synthesis

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