3-(ISOPROPYLAMINO)-PROPAN-1-OL synthesis
- Product Name:3-(ISOPROPYLAMINO)-PROPAN-1-OL
- CAS Number:33918-15-9
- Molecular formula:C6H15NO
- Molecular Weight:117.19
75-31-0
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627-18-9
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33918-15-9
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Yield:33918-15-9 90%
Reaction Conditions:
at 50; for 12 h;
Steps:
1 Step 1-3-(Isopropylamino)propan-1-ol
A solution of 3-bromopropan-1-ol (5.00 g, 36.0 mmol) in propan-2-amine (6.19 g, 105 mmol) was stirred at 50° C. for 12 hours. On completion, the mixture was concentrated to give the title compound (7.00 g, 90% yield, 50% purity) as colorless oil. 1H NNR (400 MHz, CDCl3) δ 3.84 (t, J=5.6 Hz, 2H), 3.40-3.33 (i, 1H), 3.12 (t, J=6.4 Hz, 2H), 2.11-1.99 (i, 2H), 1.39 (d, J=6.6 Hz, 6H).
References:
Kymera Therapeutics, Inc.;Mainolfi, Nello;Ji, Nan;Kluge, Arthur F.;Weiss, Matthew M.;Zhang, Yi US2019/192668, 2019, A1 Location in patent:Paragraph 4203; 4204
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33918-15-9
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