ChemicalBook CAS DataBase List Propranolol hydrochloride

Propranolol hydrochloride synthesis

5synthesis methods

Product Name:Propranolol hydrochloride
CAS Number:318-98-9
Molecular formula:C16H22ClNO2
Molecular Weight:295.8

An alkylation reaction between 1-naphthol and epichlorohydrin gives 3- (1-naphthyloxy)-1,2-epoxypropane; then a ring-opening reaction with isopropylamine gives propranolol; and finally a salt-forming reaction with hydrochloric acid gives propranolol hy

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Yield:318-98-9 99.92%

Reaction Conditions:

Stage #1: propranololwith pyrographite in ethanol;water; for 1.5 h;Reflux;
Stage #2: with hydrogenchloride in ethanol;water at 10 - 30; pH=1.5; for 18 h;Time;

Steps:

1.3; 2.3; 1.3; 2.3; 3.3; 4.3

(3) Then propranolol is subjected to a salt-forming reaction, and propranolol hydrochloride is obtained after the reaction. The specific salt-forming reaction is: adding anhydrous ethanol to the reactor, adding propranolol, propranolol and anhydrous The mass ratio of water to ethanol is 1:2.0. After dissolving, add 5% by mass of propranolol medicinal charcoal, heat up to reflux, keep refluxing for 1.5 hours,After heat preservation and reflux, press and filter to the crystallization kettle while it is hot.The jacket is frozen to 30,Add hydrochloric acid to adjust the pH to 1.5,Continue to cool to below 10°C,Crystallization for 18h,It was washed with absolute ethanol until the washing solution became colorless and then spin-dried, and dried at 60°C to obtain propranolol hydrochloride. The yield of propranolol hydrochloride was 98.6%, and the purity of propranolol hydrochloride was 99.92%.

References:

CN113336656,2021,A Location in patent:Paragraph 0015; 0019; 0022-0023; 0026-0033; 0037-0038; 0042

90-15-3 Synthesis