Propafenone Hydrochloride synthesis
- Product Name:Propafenone Hydrochloride
- CAS Number:34183-22-7
- Molecular formula:C21H28ClNO3
- Molecular Weight:377.9
107-10-8
379 suppliers
$10.00/20mg
22525-95-7
141 suppliers
$65.00/100 g
34183-22-7
371 suppliers
$6.00/250mg
Yield:34183-22-7 74.5%
Reaction Conditions:
Stage #1:propylamine;1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one at 20 - 50; for 6 h;
Stage #2: with hydrogenchloride for 1 h;Reflux;
Steps:
5 Example 5
In the reactor, add 248g of 2'-hydroxydihydrochalcone sodium salt,Epichlorohydrin 1L,Heated at 110 for 8 hours,After the reaction is complete,The excess epichlorohydrin was distilled off under reduced pressure, and the residue was cooled to room temperature,Add 600g of n-propylamine and heat to 50 for 6 hours,After the reaction is completed, the excess n-propylamine is distilled off under reduced pressure,Add 1.5L of 10% hydrochloric acid to the remainder and heat to reflux for 1 hour to cool down and crystallize,Filter, filter cake recrystallized with 95% ethanol,Finally getThe target product, propafenone hydrochloride 281g, yield 74.5%.
References:
Linyi University;Zhou Jinchuan;Zhang Haijuan;Zhang Chun;Shi Xiaowei;Zhao Zhilong;Li Haigang CN111217690, 2020, A Location in patent:Paragraph 0049-0050
1214-47-7
231 suppliers
$26.89/5g
34183-22-7
371 suppliers
$6.00/250mg
3516-95-8
234 suppliers
$13.00/5G
34183-22-7
371 suppliers
$6.00/250mg