ChemicalBook CAS DataBase List 3-METHYL-2-CYCLOHEXEN-1-OL

3-METHYL-2-CYCLOHEXEN-1-OL synthesis

12synthesis methods

Product Name:3-METHYL-2-CYCLOHEXEN-1-OL
CAS Number:21378-21-2
Molecular formula:C7H12O
Molecular Weight:112.17

591-49-1 Synthesis

591-49-1
156 suppliers
$10.00/1g

1193-18-6 Synthesis

1193-18-6
192 suppliers
$6.00/1g

21378-21-2
63 suppliers
$54.70/1g

23758-27-2 Synthesis

23758-27-2
6 suppliers
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1713-33-3
63 suppliers
$28.00/250mg

Yield: 32 %Chromat. ， 27.5 %Chromat. ， 16.3 %Chromat. ， 24.2 %Chromat.

Reaction Conditions:

with FeCl₃(5-chlorobenzotriazole)₂·2(5-chlorobenzotriazole);dihydrogen peroxide in water;acetonitrile at 26; for 2 h;Inert atmosphere;Reagent/catalyst;Time;

Steps:

2.2. Catalytic experiments
General procedure: All substrates were purchased from Aldrich, in their highest commercial purity, stored at 5 °C and purified by passage through a column of basic alumina prior to use. A 30% aqueous solution of H₂O₂ was used as oxidant. For the catalytic evaluation, H₂O₂ (30%)diluted in MeCN (1:10 v/v) was slowly added (within a period of10 min) to an MeCN solution of the iron(III) complex (the catalyst) and the substrate under an Ar atmosphere at room temperature (26 °C). Acetophenone or bromobenzene were used as internal standard. Catalytic reactions started by adding the oxidant into the reaction mixture. The catalyst:oxidant:substrate ratio was 1:20:1000 μmol for cyclohexene, 1-methylcyclohexene, cyclooctene, limonene, cyclohexane and n-hexane, and 1:50:1000 μmol for styrene, trans-β-methyl styrene and cis-stilbene. The total volume of the catalytic reaction solution was 1 ml. The large excess of the substrate was expected to minimize over-oxidation of oxidation products and to protect the catalyst from oxidative destruction. The oxidant was added slowly in order to minimize potential iron-catalyzed H₂O₂ decomposition via catalase activity.The progress of the catalytic reaction was monitored using GC-MS by removing small samples of the reaction mixture. GC analysis was performed using a 8000 Fisons chromatograph witha flame ionization detector and a Shimadzu GC-17A gas chromatograph coupled with a GCMS-QP5000 mass spectrometer. The yields reported herein are based on the amount of H₂O₂ oxidant converted into oxygenated products. Reactions were complete within 6 h. In some cases, oxidations catalyzed by [FeCl₃(5ClbtaH)₂]_*2(5ClbtaH) were accomplished within 2 h (vide infra). To establish the identity of the products unequivocally, the retention times and spectral data were compared to those of the commercially available compounds. Black experiments revealed that no oxidative reactions took place without the catalyst.

References:

Anastasiadis, Nikolaos C.;Bilis, George;Plakatouras, John C.;Raptopoulou, Catherine P.;Psycharis, Vassilis;Beavers, Christine;Teat, Simon J.;Louloudi, Maria;Perlepes, Spyros P. [Polyhedron,2013,vol. 64,p. 189 - 202]

1193-18-6 Synthesis

1193-18-6
192 suppliers
$6.00/1g

21378-21-2
63 suppliers
$54.70/1g

References

591-49-1 Synthesis

591-49-1
156 suppliers
$10.00/1g

1193-18-6 Synthesis

1193-18-6
192 suppliers
$6.00/1g

21378-21-2
63 suppliers
$54.70/1g

1713-33-3
63 suppliers
$28.00/250mg

References

591-48-0 Synthesis