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ChemicalBook CAS DataBase List Shikimic acid
138-59-0

Shikimic acid synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: imidazole / dimethylformamide / 1.75 h
2: 1.) H2O, AcOH; 2.) N,N-dimethylolpyridine / 1.) methanol, toluene, r.t., 1 h; 2) ether, 1 h
3: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 5 °C
4: 90 percent / aq.NaOH / methanol / 2.5 h / 5 - 25 °C

References:

Zamir, Lolita O.;Luthe, Corinne [Canadian Journal of Chemistry,1984,vol. 62,p. 1169 - 1175]

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