Luteolin synthesis
- Product Name:Luteolin
- CAS Number:491-70-3
- Molecular formula:C15H10O6
- Molecular Weight:286.24
855-97-0
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491-70-3
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Yield:491-70-3 89%
Reaction Conditions:
with pyridine hydrochloride at 190; for 6 h;Inert atmosphere;
Steps:
Luteolin (1)
A mixture of compound 5 (1.7 g, 5 mmol) and excess pyridine hydrochloride (5.8 g, 0.05 mol) was heated at 190 °C for 6 h under a N2 atmosphere. The mixture was then cooled to room temperature and H2O (100 mL) was added. The mixture was stirred for another 1 h and cooled to approximately 0 °C for several hours. The precipitate was filtered off, washed with water and recrystallised from ethyl acetate to give compound 1 as yellow crystals (1.3 g, 89%); m.p.329-330 °C (lit.39 328-330 °C); IR νmax (KBr/cm-1): 3490 (OH), 1664(C=O)1H NMR (500 MHz, DMSO-d6) (δ, ppm): 12.95 (s, 1H, OH),10.86 (s, 1H, OH), 9.95 (s, 1H, OH), 9.44 (s, 1H, OH), 7.43-7.41 (m, 1H),7.39 (d, J = 2.1 Hz, 1H), 6.89 (d, J = 8.3 Hz, 1H), 6.68 (s, 1H), 6.44 (d,J = 1.9 Hz,1H), 6.19 (d, J = 1.9 Hz, 1H); MS (m/z): 309 [M+Na]+.
References:
Wang, Qian;Zhang, Ji;Liu, Man;Yang, Jian;Zhang, Xiang-Ming;Zhou, Lei;Cao, Lang;Liao, Xia-Li [Journal of Chemical Research,2015,vol. 39,# 9,p. 550 - 552]
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491-70-3
579 suppliers
$5.00/100mg