3-Nitro-5-(trifluoromethyl)phenol synthesis
- Product Name:3-Nitro-5-(trifluoromethyl)phenol
- CAS Number:349-57-5
- Molecular formula:C7H4F3NO3
- Molecular Weight:207.11
328-79-0
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349-57-5
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Yield: 96%
Reaction Conditions:
with hydrogen bromide;acetic acid in waterHeating / reflux;
Steps:
3.1
A solution of 3-nitro-5-(trifluoromethyl)phenyl ether (20.0 g, 0.090 mol) in HBr (74.7 mL, 1.38 mmol) and HOAc (279.8 mL, 4.92 mol) was heated at reflux until reaction was judged to be complete by LCMS. The reaction was concentrated to tan solid to yield the desired product (18.7 g, 96% yield). LCMS: (FA) ES- 206.2 (M-1).
References:
Millennium Pharmaceuticals, Inc. US2006/160803, 2006, A1 Location in patent:Page/Page column 138
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349-57-5
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![1,1'-OXYBIS[3-NITRO-5(TRIFLUOROMETHYL)BENZENE]](/CAS/GIF/133532-73-7.gif)
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393-75-9
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349-57-5
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454-73-9
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349-57-5
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