3-(Phenoxymethyl)benzonitrile synthesis
- Product Name:3-(Phenoxymethyl)benzonitrile
- CAS Number:57928-72-0
- Molecular formula:C14H11NO
- Molecular Weight:209.24
Yield:57928-72-0 97%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 16 h;
Steps:
575
3-Bromomethylbenzonitrile (5.00 g, 25.5 mmol) was dissolved in N,N-dimethylformamide (50 ml_), phenol (2.40 g, 25.5 mmol) and potassium carbonate (10.6 g, 77 mmol) were added. The mixture was stirred at room temperature for 16 hours. The mixture was poured into water (400 ml_) and extracted with ethyl acetate (2 x 200 ml_). The combined organic extracts were washed with water (2 x 100 ml_), dried (MgSO4) and evaporated jn vacuo to afford 5.19 g (97 %) 3-(phenoxymethyl)benzonitrile as an oil.TLC: Rf = 0.38 (Ethyl acetate/heptane = 1 :4)
References:
WO2006/82245,2006,A1 Location in patent:Page/Page column 260
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