3-（trifluoromethyl) Cinnamaldehyde synthesis
- Product Name:3-（trifluoromethyl) Cinnamaldehyde
- CAS Number:262268-58-6
- Molecular formula:C10H7F3O
- Molecular Weight:200.16
454-89-7
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75-07-0
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262268-58-6
104 suppliers
$115.00/5g
Yield: 75%
Reaction Conditions:
with 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran at 20 - 25; for 48 h;Reagent/catalyst;Solvent;
Steps:
1 The preparation method of m-trifluoromethyl cinnamaldehyde
In a four-necked flask, 17.41 g of m-trifluoromethylbenzaldehyde (0.1 mol), 68.0 mL of tetrahydrofuran and 3.04 g of DBU (0.02 mol), freshly distilled 11.01 g of acetaldehyde (0.25 mol) was added with stirring, and the mixture was stirred at room temperature (20 to 25C)Stirring 48h, sampling, HPLC control, to the raw material disappeared, the end of the reaction.Maintain the material temperature below 30 under reduced pressure distillation, remove excess acetaldehyde and solvent, and then add 1mol / L dilutionHydrochloric acid to pH 3 to 5, extracted with dichloromethane, and the organic phase was concentrated under reduced pressure to remove the solvent and distilled under reduced pressure to give a colorless oilWas obtained in a yield of 15.0g, 75.0% and a purity of 98.5% (HPLC).
References:
Changzhou Sunshine Pharmaceutical Co., Ltd.;Hu Guoyi;Hu Jinping;Zheng Jianlong;Xi Xiaojin CN106748695, 2017, A Location in patent:Paragraph 0020; 0021
454-89-7
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$14.00/25g
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262268-58-6
104 suppliers
$115.00/5g
401-81-0
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262268-58-6
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$115.00/5g
113048-69-4
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262268-58-6
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401-78-5
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3054-95-3
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70311-33-0
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262268-58-6
104 suppliers
$115.00/5g