一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-(2,3-EPOXYPROPYL)MORPHOLINE
6270-19-5

4-(2,3-EPOXYPROPYL)MORPHOLINE synthesis

2synthesis methods
-

Yield: 88.8%

Reaction Conditions:

Stage #1:morpholine;epichlorohydrin in tert-butyl alcohol at 0 - 20;Cooling with ice-water;
Stage #2: with potassium tert-butylate in tetrahydrofuran;tert-butyl alcohol at 10;Cooling with ice-water;

Steps:

53.1
Step 1 4-Oxiranylmethyl-morpholine Morpholine 53a (8.712 ml, 0.1 mol) was dissolved in tert-butanol (4.5 ml) under stirring at room temperature, and (R)-(-)-1-chloro-2,3-epoxypropane (8.05 ml, 0.1 mol) was added slowly to the solution at 0° C. in an ice-water bath. Upon completion of the addition, the ice-water bath was removed, and the reaction mixture was allowed to warm up to room temperature and stirred for 24 hours. After thin lay chromatography showed the disappearance of starting materials, the reaction mixture was added dropwise with a solution of potassium tert-butoxide in tetrahydrofuran (60 ml, 1.67 mol/L, 100 mmol) while maintaining the temperature below 10° C. in an ice-water bath, gradually turned from light yellow to white turbid solution and stirred for 30 minutes. After thin lay chromatography showed the disappearance of starting materials, the reaction mixture was concentrated under reduced pressure, added with water (50 ml), exacted with dichloromethane (100 ml*2). The combined organic extracts were washed with saturated brine (100 ml), dried over anhydrous magnesium sulfate, filtered to remove the drying agent and concentrated under reduced pressure to obtain the title compound 4-oxiranylmethyl-morpholine 53b (12.7 g, yield 88.8%) as a yellow oil.

References:

ChoTang, Peng Cho;Su, Yidong;Li, Yali;Zhang, Lei;Zhao, Fuqiang;Yang, Jialiang;Zhou, Ying;Bie, Pingyan;Qian, Guangtao;Ju, Minggang US2010/75952, 2010, A1 Location in patent:Page/Page column 75

4-(2,3-EPOXYPROPYL)MORPHOLINE Related Search:

民县| 巫山县| 大方县| 永寿县| 仲巴县| 永嘉县| 罗江县| 无为县| 甘洛县| 昔阳县| 株洲县| 和静县| 大丰市| 新宁县| 石泉县| 藁城市| 诸暨市| 十堰市| 宁南县| 西吉县| 深泽县| 三门县| 鲁山县| 汝城县| 遂宁市| 德保县| 镇远县| 横山县| 米脂县| 晋宁县| 西充县| 南川市| 临武县| 婺源县| 灌南县| 乌兰察布市| 绥芬河市| 泰顺县| 松江区| 翁牛特旗| 太湖县|