4-(2-METHYL-4-NITRO-PHENYL)-MORPHOLINE synthesis
- Product Name:4-(2-METHYL-4-NITRO-PHENYL)-MORPHOLINE
- CAS Number:223404-63-5
- Molecular formula:C11H14N2O3
- Molecular Weight:222.24
110-91-8
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1427-07-2
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223404-63-5
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Yield:223404-63-5 98%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 100; for 2 h;Green chemistry;
Steps:
Substrate preparation:
General procedure: A mixture of morpholine (2.62 g, 30mmol), potassium carbonate (4.14g, 30 mmol) and 4-fluoronitrobenzene(2.82 g, 20 mmol) in DMSO (10 mL) was stirred at 100 for 2h. After completion of thereaction, the mixture was allowed to cool to room temperature, and water (50 mL) was added. The solidswere collected by filtration, washed by water, and dried, 4.08g of 1a was obtained as a yellow solid (98%yield).
References:
Liu, Chaoyang;Sun, Haozhou;Qin, Cheng;Yang, Tiannuo;Zhang, Wenxian;Zhou, Yuan;Li, Yani;Jia, Zheng Robert;Chu, Changhu [Synlett,2022,vol. 33,# 10,p. 993 - 997] Location in patent:supporting information
110-91-8
710 suppliers
$9.00/1g
455-88-9
320 suppliers
$6.00/10g
223404-63-5
51 suppliers
$291.00/1g
455-88-9
320 suppliers
$6.00/10g
109-85-3
279 suppliers
$10.00/1g
223404-63-5
51 suppliers
$291.00/1g