4-(2-OXOACETYL)BENZONITRILE synthesis
- Product Name:4-(2-OXOACETYL)BENZONITRILE
- CAS Number:20099-53-0
- Molecular formula:C9H5NO2
- Molecular Weight:159.14
1443-80-7
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Yield:20099-53-0 85%
Reaction Conditions:
with selenium(IV) oxide;water in 1,4-dioxane at 90; for 12 h;
Steps:
1
Synthesis of4-(2-oxo-acetyl)-benzonitrile 1.7.a; To a mixture of dioxane (75 ml) and water (7.5 ml), selenium oxide (100 mmol) was added. The mixture was stirred at 50°C until the selenium oxide was dissolved. Then para-cyano-acetophenone (100 mmol) was added. The mixture was stirred at 90°C for 12 hours. The warm solution was filtered and the solvent was removed. The residue obtained was dissolved in dichloromethane and water was added. The organic layer was separated, dried on magnesium sulphate and the solvent was removed, yielding intermediate 1.7. a as a solid (85%).
References:
WO2005/105810,2005,A2 Location in patent:Page/Page column 27
20099-89-2
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3032-92-6
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