4,5-DICHLOROPHTHALIC ANHYDRIDE synthesis
- Product Name:4,5-DICHLOROPHTHALIC ANHYDRIDE
- CAS Number:942-06-3
- Molecular formula:C8H2Cl2O3
- Molecular Weight:217.01
56962-08-4
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$18.00/1g
942-06-3
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$20.00/1G
Yield:942-06-3 100%
Reaction Conditions:
with acetyl chloride for 2 h;Reflux;
Steps:
5.1.19 5,6-Dichlorophthalic anhydride (40)
Diacid 39 (10.00 g, 42.55 mmol) was suspended in AcCl (50 mL) and the mixture was heated at reflux with stirring for 2 h.
The obtained suspension was concentrated in vacuo and azeotroped with hexanes (2 * 10 mL) and PhMe (2 * 10 mL) to provide anhydride 40 (9.23 g, 100%) as a beige powder, Rf (SiO2, CHCl3) 0.64: mp 185-189 °C. 1H NMR (500 MHz, CDCl3) δ 8.10 (s, 2H); CIMS m/z (rel intensity) 217/219/221 (MH+, 100/69/12).
References:
Beck, Daniel E.;Lv, Wei;Abdelmalak, Monica;Plescia, Caroline B.;Agama, Keli;Marchand, Christophe;Pommier, Yves;Cushman, Mark [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 7,p. 1469 - 1479]
88-99-3
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942-06-3
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$20.00/1G
85-44-9
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$9.00/5g
118-45-6
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117-21-5
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942-06-3
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51971-64-3
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85-44-9
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7664-93-9
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$21.64/1003
7553-56-2
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$18.00/25g
7782-50-5
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$373.00/454g
942-06-3
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$20.00/1G
4466-59-5
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$57.50/250 mg
56962-07-3
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