4-(Aminomethyl)piperidine synthesis
- Product Name:4-(Aminomethyl)piperidine
- CAS Number:7144-05-0
- Molecular formula:C6H14N2
- Molecular Weight:114.19
4395-98-6
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7144-05-0
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Yield:7144-05-0 92%
Reaction Conditions:
with hydrogen in ethanol at 88; under 45004.5 Torr; for 1 h;
Steps:
5
In the 1L hydrogenation kettle, add 100 g of 4-piperidine carbonitrile and 3 g of Raney-Ni, 400 mL of ethanol, and continuously charged with H2, so that the pressure of the system during the reaction was always maintained at 6 MPa. After reaction at a reaction temperature of 88 ° C for 1 h, then the temperature was lowered. When the temperature in the reaction vessel was lowered to room temperature, the gas was vented, and 4-piperidine methyl amine (purity: 99% or more) was obtained by filtration and recrystallization in a yield of 92 wt%.
References:
Sinopec Corporation;Sinopec Yangzi Petrochemical Co., Ltd.;Sun Hailong;Wei Yanyu;Gao Yilong;Chen Xinhua;Miao Jun;Li Na;Kan Lin;Bai Jiye;Chen Shaohui;Yang Aiwu;Xu Yuexing CN104557356, 2017, B Location in patent:Paragraph 0240
![1-Piperidinecarboxylic acid, 4-[[[(phenylmethoxy)carbonyl]amino]methyl]-, phenylmethyl ester](/CAS/20210305/GIF/132431-14-2.gif)
132431-14-2
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132431-09-5
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7144-05-0
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498-94-2
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7144-05-0
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39546-32-2
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7144-05-0
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