4-Bromo-3,5-dimethylphenol synthesis
- Product Name:4-Bromo-3,5-dimethylphenol
- CAS Number:7463-51-6
- Molecular formula:C8H9BrO
- Molecular Weight:201.06
108-68-9
7463-51-6
General procedure for the synthesis of 4-bromo-3,5-dimethylphenol from 3,5-dimethylphenol: To a mixture of 3,5-dimethylphenol (0.7 mmol) was added a dichloromethane (30 mL)-methanol (15 mL) solution of brominating agent (1) (0.72 g, 0.7 mmol). The reaction mixture was stirred at room temperature until the orange solution faded. The progress of the reaction was monitored by thin layer chromatography (TLC) (eluent: hexane/ethyl acetate, 7:3). After completion of the reaction, the solvent was evaporated and ether (10 mL) was added to the residue. The supernatant was decanted and the insoluble residue was washed with ether (3 x 10 mL). The ether extracts were combined, dried with magnesium sulfate, and the solvent was evaporated under vacuum to obtain the crude 4-bromo-3,5-dimethylphenol. The target product was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate, 7:3).
874-63-5
179 suppliers
$5.00/1g
7463-51-6
277 suppliers
$9.00/10g
Yield:-
Steps:
Multi-step reaction with 2 steps
1: N-Bromosuccinimide
2: boron tribromide / dichloromethane / 2 h / 0 °C
References:
Zhang, Yanmei;Tortorella, Micky D.;Wang, Yican;Liu, Jianqi;Tu, Zhengchao;Liu, Xiaorong;Bai, Yang;Wen, Dingsheng;Lu, Xin;Lu, Yongzhi;Talley, John J. [ACS Medicinal Chemistry Letters,2014,vol. 5,# 10,p. 1162 - 1166]
108-68-9
335 suppliers
$9.00/5g
7463-51-6
277 suppliers
$9.00/10g
6267-34-1
122 suppliers
$19.00/5g
7463-51-6
277 suppliers
$9.00/10g
672-99-1
31 suppliers
$180.00/1g
7463-51-6
277 suppliers
$9.00/10g