3,5-Dimethylphenol synthesis
- Product Name:3,5-Dimethylphenol
- CAS Number:108-68-9
- Molecular formula:C8H10O
- Molecular Weight:122.16
22445-41-6
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108-68-9
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Yield:108-68-9 99%
Reaction Conditions:
with copper oxide (I);2-(N,N-dimethylamino)ethanol;lithium hydroxide monohydrate;potassium hydroxide in dimethyl sulfoxide at 100; for 24 h;Inert atmosphere;Reagent/catalyst;Temperature;
Steps:
General Procedure B.
To a test tube containing a magnetic bar was added aryl halide (1.0 mmol), Cu2O (14.3 mg, 0.1 mmol), KOH (169 mg, 3.0 mmol), 2-dimethylaminoethanol (0.3 mL, 3.0 mmol), and DMSO/H2O (1.5 mL/0.5 mL). After flushing with argon, the mixture was stirred in a preheated oil bath at 100 °C for 24 h. After cooled to ambient temperature, the reaction mixture was distributed in aqueous HCl (5 %) and ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous MgSO4, and concentrated under vacuum. The crude product was further purified by column chromatography (EtOAc/n-Hexane) to provide the phenols.
References:
Kim, Jihye;Battsengel, Oyunsaikhan;Liu, Yajun;Chae, Junghyun [Bulletin of the Korean Chemical Society,2015,vol. 36,# 12,p. 2833 - 2840] Location in patent:supporting information
172975-69-8
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108-68-9
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108-68-9
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