4-Chloro-3,5-dimethylphenol synthesis
- Product Name:4-Chloro-3,5-dimethylphenol
- CAS Number:88-04-0
- Molecular formula:C8H9ClO
- Molecular Weight:156.61
108-68-9
335 suppliers
$9.00/5g
88-04-0
595 suppliers
$5.00/10g
Yield:88-04-0 98.9%
Reaction Conditions:
with N-chloro-N-(phenylsulfonyl)benzenesulfonamide in acetonitrile at 20 - 25; for 0.166667 h;Green chemistry;
Steps:
General procedure for the monochlorination reaction
General procedure: To a solution of 4-nitroaniline, 1a (0.99 g, 7.2 mmol) in 7 mL specially dried MeCN was added N-chloro-N-(phenylsulfonyl)benzene sulfonamide (2.4 g, 7.2 mmol) in a 25 mL round bottom flask. The reaction mixture was stirred for 10-15 minutes at 20-25 °C (0 °C for 1-methyl-1H-imidazole, and N-methylindole), monitored by GC. After completion of the reaction, MeCN was distilled under vacuum at 40-45 °C. The residue was treated with 20 mL mixture of MDC and water, stirred the mixture for 10-15 minutes; MDC layer was separated and washed with 5 % sodium bicarbonate solution, after separation MDC layer was dried over sodium sulfate and evaporated under vacuum to obtain 2-chloro-4-nitroaniline, 2a, 1.22 g (98.5 % yield, 98.9 % purity) as a yellow powder.
References:
Misal, Balu;Palav, Amey;Ganwir, Prerna;Chaturbhuj, Ganesh [Tetrahedron Letters,2021,vol. 63,art. no. 152689] Location in patent:supporting information
108-68-9
335 suppliers
$9.00/5g
88-04-0
595 suppliers
$5.00/10g
133-53-9
285 suppliers
$9.00/25g
5538-41-0
70 suppliers
$75.00/100mg
874-63-5
179 suppliers
$5.00/1g
88-04-0
595 suppliers
$5.00/10g
6981-15-3
12 suppliers
inquiry
88-04-0
595 suppliers
$5.00/10g