4-Bromo diphenylacetylene synthesis
- Product Name:4-Bromo diphenylacetylene
- CAS Number:13667-12-4
- Molecular formula:C14H9Br
- Molecular Weight:257.13
5467-74-3
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13667-12-4
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Yield: 96%
Reaction Conditions:
with C26H22N3OPPdS;potassium acetate;silver(l) oxide in dichloromethane at 35; for 24 h;Schlenk technique;Inert atmosphere;
Steps:
4.2.8. 1-Bromo-4-(phenylethynyl)benzen
A mixture of arylboronic acid (0.5 mmol), terminal alkyne oralkynyl carboxylic acid (0.6 mmol), DCM (2 mL), catalyst 3 (2 mol %),Ag2O (1.0 mmol) and KOAc (1.0 mmol) in a Schlenk tube was stirredunder an argon atmosphere at 35 Cfor24h.TheexcessDCMwasthen removed by rotary evaporation and the residue was directlypuried by ash column chromatography (petroleum ether or pe-troleum ether/ethyl acetate) to afford the corresponding couplingproducts. 4.2.8. 1-Bromo-4-(phenylethynyl)benzen 32b(Table 1, entry 8)(123 mg, 96% yield). White solid, mp: 82e83C;1HNMR (400 MHz,CDCl3) d 7.56e7.50 (m, 2H), 7.48 (d, J8.1 Hz, 2H), 7.42e7.31 (m,5H).13C NMR (100 MHz, CDCl3)d133.1, 131.6, 131.6, 128.5, 128.4,122.9, 122.5, 122.3, 90.5, 88.3.
References:
Lu, Linhua;Chellan, Prinessa;Smith, Gregory S.;Zhang, Xiang;Yan, Hong;Mao, Jincheng [Tetrahedron,2014,vol. 70,# 35,p. 5980 - 5985]
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13667-12-4
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$32.00/250mg
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13667-12-4
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13667-12-4
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$32.00/250mg
536-74-3
314 suppliers
$10.00/1g
13667-12-4
73 suppliers
$32.00/250mg