4-Bromophenylacetylene synthesis
- Product Name:4-Bromophenylacetylene
- CAS Number:766-96-1
- Molecular formula:C8H5Br
- Molecular Weight:181.03
Under nitrogen protection, 25 mL of triethylamine, 1.415 g (5.0 mmol) of 4-bromoiodobenzene, 420 mg (5.0 mmol) of 2-methyl-3-butyn-2-ol, and 70 mg (0.1 mmol) of bis(triphenylphosphine)palladium dichloride (Pd(PPh3)2Cl2), triphenylphosphine ( PPh3) 105
90965-06-3
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$30.25/1g
1122-91-4
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$9.00/10g
766-96-1
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$7.00/250mg
Yield:766-96-1 92%
Reaction Conditions:
with potassium carbonate in methanol at 20; for 12 h;
Steps:
General procedure A to obtain ethynyl derivatives:
General procedure: To a solutionof dimethyl 1-diazo-2-oxopropylphosphonate (1.15 g,6.00 mmol) in MeOH (60 mL) were added the corresponding aldehydes(5.00 mmol) and K2CO3 (1.38 g, 10.0 mmol). The reactionmixture was stirred at room temperature for 12 h. After removingthe volatiles without any heating, alkynes 6e9 were purified byflash chromatography using a mixture of petroleum ether andEtOAc 99/1 as eluent.
References:
Ouach, Aziz;Vercouillie, Johnny;Bertrand, Emilie;Rodrigues, Nuno;Pin, Frederic;Serriere, Sophie;Boiaryna, Liliana;Chartier, Agnes;Percina, Nathalie;Tangpong, Pakorn;Gulhan, Zuhal;Mothes, Celine;Deloye, Jean-Bernard;Guilloteau, Denis;Page, Guylene;Suzenet, Franck;Buron, Frederic;Chalon, Sylvie;Routier, Sylvain [European Journal of Medicinal Chemistry,2019,vol. 179,p. 449 - 469]
16116-78-2
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766-96-1
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$7.00/250mg
76347-62-1
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$95.00/1 g
766-96-1
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589-87-7
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1066-54-2
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766-96-1
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$7.00/250mg
99-90-1
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$6.00/25g
766-96-1
230 suppliers
$7.00/250mg