4-CHLORO-2,6-DIPHENYLPYRIMIDINE synthesis
- Product Name:4-CHLORO-2,6-DIPHENYLPYRIMIDINE
- CAS Number:29509-91-9
- Molecular formula:C16H11ClN2
- Molecular Weight:266.72
3764-01-0
24388-23-6
29509-91-9
Using 2,4,6-trichloropyrimidine (10 g, 54.5 mmol) and (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (22.3 g, 109 mmol) as raw material, catalyzed by tetrakis(triphenylphosphine)palladium (3.8 g, 3.27 mmol) in a mixed solvent of THF (240 mL) and water (120 mL). Potassium carbonate (45.2 g) was added and the reaction was stirred at 90 °C. Upon completion of the reaction, extraction was carried out with dichloromethane and water. The organic layer was dried with anhydrous magnesium sulfate and concentrated. Purified by silica gel column chromatography and recrystallization, 9.5 g of 4-chloro-2,6-diphenylpyrimidine was obtained in 65% yield.
Yield: 75%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);tetrabutylammomium bromide;sodium hydroxide in water;toluene at 80; for 12 h;Inert atmosphere;
Steps:
8.1 1) Synthesis of Intermediate 1-38-2:
According to the synthesis method of compound 1-3-3, (12.2g, 100mmol) of compound 1-23-3 and (22.5g, 100mmol) of compound 1-38-1 were substituted for compound 1-3-1 and compound 1- 3-2, the yield is 75%.
References:
Guangzhou Huarui Optoelectric Materials Co., Ltd.;He Ruifeng;Huang Hong;Wu Canjie;Song Jingyao CN111848590, 2020, A Location in patent:Paragraph 0251-0256
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