4-Chloroindole synthesis
- Product Name:4-Chloroindole
- CAS Number:25235-85-2
- Molecular formula:C8H6ClN
- Molecular Weight:151.59
1) Synthesis of N,N-dimethyl-2-chloro-6-nitrostyrene amine: 200g of 2-chloro-6-nitrotoluene, 183g of DMFDMA was added to 150ml of anhydrous DMF solution, heated to 80-120 ℃, the reaction was kept warm for 4 hours, and the end point of the reaction was
83-42-1
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: 89 percent / CuI; DMF / 0.33 h / 180 °C / 6000.6 - 7500.75 Torr / microwave irradiation
2: 74 percent / Zn; AcOH / methanol; CH2Cl2 / Heating
References:
Siu, Jason;Baxendale, Ian R.;Ley, Steven V. [Organic and Biomolecular Chemistry,2004,vol. 2,# 2,p. 160 - 167]
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