一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-Chloroindoline
41910-64-9

4-Chloroindoline synthesis

5synthesis methods
4-Chloroindole

25235-85-2

4-Chloroindoline

41910-64-9

GENERAL STEPS: The synthesis of 4-chloroindoline from 4-chloroindole was carried out as follows: 4-chloroindole (20.0 g, 148 mmol) was dissolved in acetic acid (60 mL), followed by the addition of sodium cyanoborohydride (18.7 g, 296 mmol) in batches. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was slowly poured into 1500 mL of a 2 M NaOH aqueous solution. The aqueous phase was extracted with dichloromethane (CH2Cl2) and the organic layers were combined. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give 4-chloroindoline (20.0 g, 98% yield). The product was confirmed by 1H NMR (400MHz, CDCl3): δ3.08 (2H, triple peak, J=8.4Hz), 3.62 (2H, triple peak, J=8.4Hz), 6.62-6.66 (1H, multiple peaks), 6.78-6.83 (1H, multiple peaks), 6.90 (1H, double double peaks, J=7.6,0.4Hz).

25235-85-2 Synthesis
4-Chloroindole

25235-85-2
329 suppliers
$6.00/1g

-

Yield: 99%

Reaction Conditions:

Stage #1:4-chloro-1H-indole with sodium cyanoborohydride;acetic acid in N,N-dimethyl-formamide at 20; for 2 h;
Stage #2: with water;sodium hydroxide in N,N-dimethyl-formamide

Steps:

14 5.1.14. 4-Chloro-2,3-dihydro-1H-indole (15b)
General procedure: 5.1.24. 7-Fluoro-2,3-dihydro-1H-indole (15f) 7-Fluoro-1H-indole (20.0 g, 148 mmol) was dissolved in acetic acid (60 mL) and sodium cyanoborohydride (18.7 g, 296 mmol) was added in portions. The mixture was stirred for 2 h and then poured into 1500 mL of 2 M aqueous NaOH solution. The mixture was extracted with CH2Cl2. The organic layers were combined, washed with brine, dried over MgSO4, and concentrated under reduced pressure to give the title compound (20.0 g, 98%). 1H NMR (400 MHz, CDCl3) δ 3.08 (2H, t, J = 8.4 Hz), 3.62 (2H, t, J = 8.4 Hz), 6.62-6.66 (1H, m), 6.78-6.83 (1H, m), 6.90 (1H, dd, J = 7.6, 0.4 Hz).

References:

Sato, Kenjiro;Sugimoto, Hiromichi;Rikimaru, Kentaro;Imoto, Hiroshi;Kamaura, Masahiro;Negoro, Nobuyuki;Tsujihata, Yoshiyuki;Miyashita, Hirohisa;Odani, Tomoyuki;Murata, Toshiki [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 5,p. 1649 - 1666]

4-Chloroindoline Related Search:

攀枝花市| 息烽县| 永新县| 琼中| 棋牌| 刚察县| 封丘县| 娱乐| 阿克陶县| 山阳县| 丰顺县| 中宁县| 开鲁县| 尖扎县| 荆州市| 西峡县| 望江县| 大洼县| 麻江县| 临西县| 台安县| 拜泉县| 肃北| 北流市| 西丰县| 金秀| 图们市| 亳州市| 读书| 广昌县| 拉萨市| 平和县| 建平县| 沙洋县| 墨竹工卡县| 泽普县| 白玉县| 张家川| 琼结县| 浦城县| 贵南县|