4-Chloropyrimidine synthesis
- Product Name:4-Chloropyrimidine
- CAS Number:17180-93-7
- Molecular formula:C4H3ClN2
- Molecular Weight:114.53
51953-18-5
131 suppliers
$6.00/1g
17180-93-7
136 suppliers
$98.00/1g
Yield:17180-93-7 70%
Reaction Conditions:
with trichlorophosphate at 100; for 5 h;
Steps:
4 4-Chloropyrimidine
4(3H)-Pyrimidinone (401.2 mg, 4.18 mmol) and POCl3(4 mL) were charged to a pressure flask. Flask was flushed with nitrogen and heated to 100 °C for 5 h. Yellow precipitate was filtered and washed with 20 mL of hexane. Yellow-orange precipitate was dried in vacuo and used without further purification (332.3 mg, 70%).
References:
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;LI, Hui;XIE, Zhongqiu;JANCZYK, Pawel Lukasz;HILINSKI, Michael Kenneth;HAHN, Philip Lee;DOOLEY, Johnathon Daniel WO2020/223715, 2020, A1 Location in patent:Paragraph 0364; 0368
51953-17-4
139 suppliers
$25.30/1g
17180-93-7
136 suppliers
$98.00/1g
51953-17-4
139 suppliers
$25.30/1g
17180-93-7
136 suppliers
$98.00/1g