4-ETHOXY-BENZENESULFONYL CHLORIDE synthesis
- Product Name:4-ETHOXY-BENZENESULFONYL CHLORIDE
- CAS Number:1132-17-8
- Molecular formula:C8H9ClO3S
- Molecular Weight:220.67
7790-94-5
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1132-17-8
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Yield: 53%
Reaction Conditions:
in dichloromethane for 2 h;
Steps:
6.1.4. [(4-{[{4-[(Benzylmethanesulfonylamino)methyl]phenyl}(4-methoxybenzenesulfonyl)amino]methyl}phenyl)methanesulfonylamino]acetic acid methyl ester (P6)
General procedure: 11a (1.84 g, 17 mmol) was dissolved in DCM (50 mL). Thenchlorosulfonic acid (2.97 g, 25.5 mmol) in DCM (20 mL) was addedover 60 min at -5 C. The mixture was allowed to warm to roomtemperature with stirring additional 60 min. The mixture waspoured into ice water and the organic phase was separated,washed with Na2CO3, NaHCO3, water and saturated brine. It wasfinally dried over anhydrous Na2SO4, filtered and evaporated,affording in 12a (2.11 g, 60%). According to the same proceduredescribed for 13a, 10a (203 mg, 0.7 mmol) was treated with 12a(157 mg, 0.76 mmol) to afford 228 mg (71%) of 13b as a whitesolid. According to the same procedure described for P5, 13b(184 mg, 0.40 mmol) was treated with 16a (155 mg, 0.46 mmol)to afford 173 mg (61%) of P6 as a white solid.
References:
Liu, Peihong;Du, Yongli;Song, Lianhua;Shen, Jingkang;Li, Qunyi [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 21,p. 7079 - 7088]
103-73-1
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$8.00/25g
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$44.00/250 mg
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1132-17-8
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108-95-2
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1132-17-8
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$44.00/250 mg