(4-ethylphenyl)methanamine hydrochloride synthesis
- Product Name:(4-ethylphenyl)methanamine hydrochloride
- CAS Number:102494-85-9
- Molecular formula:C9H14ClN
- Molecular Weight:171.6672
1443-80-7
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Yield:102494-85-9 111 mg
Reaction Conditions:
Stage #1: 4-cyanophenyl methyl ketonewith sodium hypophosphite monohydrate;5%-palladium/activated carbon;hypophosphorous acid in water at 100;Sealed tube;
Stage #2: with hydrogenchloride in diethyl ether;
Steps:
General procedures for the ketone reduction in alkane 1-19b
General procedure: Method B: in a round bottom flask, to a solution of ketone (1mmol) and Pd/C 5wt% (50% in water) (212mg, 0.1mmol, 10mol%) in CPME (1mL) was added a mixture of sodium hypophosphite monohydrate (3mmol), hypophosphorous acid 50% in water (1mmol) in water (2mL). The reaction mixture was heated at 100°C between 2 and 16h. Same treatment as Method A was performed. (0038) Method C: the same procedure was followed replacing the thermal activation by a sonochemical activation during 5h.
References:
Guyon, Carole;Baron, Marc;Lemaire, Marc;Popowycz, Florence;Métay, Estelle [Tetrahedron,2014,vol. 70,# 12,p. 2088 - 2095]
25309-65-3
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102494-85-9
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