4-Fluorobenzophenone synthesis
- Product Name:4-Fluorobenzophenone
- CAS Number:345-83-5
- Molecular formula:C13H9FO
- Molecular Weight:200.21
Yield:345-83-5 98%
Reaction Conditions:
with NHC-Pd(II)-Im;sodium hydrogencarbonate in water at 20; for 12 h;Inert atmosphere;
Steps:
4.2. Experimental procedures
General procedure: Under N2 atmosphere, NaHCO3 (2.4 mmol), benzoic anhydride 3a (1.5 mmol), phenylboronic acid 2a (0.75 mmol), and H2O were successively added into a Schlenk reaction tube. The mixture was stirred at room temperature for about 10 min. Then NHC-Pd(II)-Im complex 1 (1.0 mol %) was added. The mixture was stirred at room temperature for 12 h and then was diluted with CH2Cl2, washed with saturated brine, dried over anhydrous Na2SO4. The dried organic phase was then filtered, concentrated under reduced pressure and purified by flash column chromatography on silica gel to give the pure product 4a.
References:
Lin, Xiao-Fang;Li, Yao;Li, Shuang-Yan;Xiao, Zheng-Kang;Lu, Jian-Mei [Tetrahedron,2012,vol. 68,# 29,p. 5806 - 5809] Location in patent:experimental part
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