(4-METHOXY-3-NITROPHENYL)ACETIC ACID synthesis
- Product Name:(4-METHOXY-3-NITROPHENYL)ACETIC ACID
- CAS Number:63304-80-3
- Molecular formula:C9H9NO5
- Molecular Weight:211.17
34837-88-2
32 suppliers
$120.00/500mg
63304-80-3
24 suppliers
$189.00/100mg
Yield: 80%
Reaction Conditions:
with lithium hydroxide monohydrate in tetrahydrofuran;water at 20; for 1 h;
Steps:
17.3 Step 3. 2-(4-methoxy-3-nitrophenyl)acetic acid
Methyl 2-(4-methoxy-3-nitrophenyl)acetate (8.0 g, 35.6 mmol) was dissolved in tetrahydrofuran (80 mL) and water (20 mL). Lithium hydroxide monohydrate (4.5 g, 106.7 mmol) was slowly added to the reaction solution, and the reaction was stirred at room temperature for 1 hour. Tetrahydrofuran was removed under reduced pressure and the pH was adjusted to 3 with hydrochloric acid (3N). The reaction mixture was stirred for 15 minutes and then filtered. The filter cake was washed with 50 mL of water and dried to give 2-(4-methoxy-3-nitrophenypacetic acid. (6.0 g, 28.4 mmol, yield: 80%). 1H NMR (400 MHz, DMSO-d6) δ 12.46 (m, 1H), 7.79 (d, J=2.4 Hz, 1H), 7.56 (dd, J=2.4 and 8.8 Hz, 1H), 7.32 (d), J=8.8 Hz, 1H), 3.91(s, 3H), 3.64(s, 2H).
References:
Shanghai Zhimeng Biophama Co., Ltd.;CHEN, Huanming US2019/152963, 2019, A1 Location in patent:Paragraph 0290; 0297-0299
104-01-8
538 suppliers
$6.00/10g
63304-80-3
24 suppliers
$189.00/100mg
10463-20-4
162 suppliers
$19.00/1g
74-88-4
349 suppliers
$15.00/10g
63304-80-3
24 suppliers
$189.00/100mg
![5(4H)-Oxazolone,4-[(4-methoxy-3-nitrophenyl)methylene]-2-phenyl-](/CAS/20180527/GIF/904-42-7.gif)
904-42-7
4 suppliers
inquiry
63304-80-3
24 suppliers
$189.00/100mg
56245-07-9
17 suppliers
inquiry
63304-80-3
24 suppliers
$189.00/100mg