4-METHYL(THIOBENZAMIDE) synthesis
- Product Name:4-METHYL(THIOBENZAMIDE)
- CAS Number:2362-62-1
- Molecular formula:C8H9NS
- Molecular Weight:151.23
104-87-0
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$6.00/25g
2362-62-1
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$12.00/250mg
Yield: 89%
Reaction Conditions:
with hydroxylamine hydrochloride;sodium acetate;O,O-Diethyl hydrogen phosphorodithioate in 1,4-dioxane at 80 - 90; for 2 h;Inert atmosphere;
Steps:
General procedure for the one-pot synthesis of thioamides 3 and 4:
General procedure: to a solution of an aldehyde or a ketone (1.0 mmol) in dioxane (2 mL) was added hydroxylamine hydrochloride (1.0 mmol), sodium acetate (1.0 mmol), and O,O-diethyl dithiophosphoric acid (2) (1.0 mmol) under nitrogen atmosphere. The reaction mixture was stirred at 80-90 °C for 2-4 h, then cooled to rt, neutralized with aqueous sodium hydrogen carbonate and extracted with EtOAc (2 × 10 mL). The combined organic phase was dried over MgSO4, filtered, and evaporated under reduced pressure. The resulting crude product was purified by silica gel column chromatography using a gradient mixture of hexane/ethyl acetate as eluent to afford the corresponding thioamide (3 or 4). All the products are known compounds and were characterized by the comparison of their mp and spectral data with those reported in the literature. 10-12
References:
Yadav, Arvind K.;Srivastava, Vishnu P.;Yadav, Lal Dhar S. [Tetrahedron Letters,2012,vol. 53,# 52,p. 7113 - 7116]
104-85-8
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$11.00/25g
2362-62-1
103 suppliers
$12.00/250mg
619-55-6
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$5.00/1g
2362-62-1
103 suppliers
$12.00/250mg
619-55-6
197 suppliers
$5.00/1g
2362-62-1
103 suppliers
$12.00/250mg
104-85-8
334 suppliers
$11.00/25g
99-94-5
617 suppliers
$9.00/1g
2362-62-1
103 suppliers
$12.00/250mg