4-METHYLPHENYLACETONE synthesis
- Product Name:4-METHYLPHENYLACETONE
- CAS Number:2096-86-8
- Molecular formula:C10H12O
- Molecular Weight:148.2
250kg of propionic acid and 185kg of phosphorus trichloride were put into 500L glass-lined reaction pot, slowly heating reaction, stirring and holding at 50 ℃ for 6h, static for 3h, divided into the l
1195-32-0
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2096-86-8
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$14.00/250mg
Yield:2096-86-8 83%
Reaction Conditions:
with oxone;sodium iodide in water;acetonitrile at 20; for 15 h;Green chemistry;
Steps:
catalytic oxidative 1,2-shift ofarylalkenes
General procedure: To a mixture solvent MeCN-H2O (5:1) (2 mL), α-methylstyrene (0.5 mmol), Oxone (1.0 mmol) and NaI (0.05 mmol) were added. The mixture was stirred at room temperature for 15 h, then H2O (5 mL) was added. Extraction of the mixture with CH2Cl2 (3 * 5 mL) and the combined organic layer was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified on silica gel plate (5:1 hexane-ethyl acetate) to give 1-phenylpropan-2-one in 81% of yield.
References:
Zhu, Min;Zhao, Yang [Chinese Chemical Letters,2015,vol. 26,# 2,p. 248 - 250]
108-22-5
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106-49-0
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2096-86-8
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624-31-7
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123-54-6
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2096-86-8
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5910-25-8
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106-38-7
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67-64-1
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2096-86-8
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2698-14-8
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2096-86-8
138 suppliers
$14.00/250mg