4-(Trifluoromethoxy)benzoic acid synthesis
- Product Name:4-(Trifluoromethoxy)benzoic acid
- CAS Number:330-12-1
- Molecular formula:C8H5F3O3
- Molecular Weight:206.12
332-25-2
330-12-1
Synthesis of 4-(trifluoromethoxy)benzoic acid: 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) was dissolved in acetic acid (12 mL), and water (12 mL) and concentrated sulfuric acid (12 mL) were added sequentially. The reaction mixture was stirred and reacted at 120 °C overnight. Upon completion of the reaction, water (100 mL) was added to the mixture and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound 4-(trifluoromethoxy)benzoic acid (4.8 g, 98% yield) as a white solid.
332-25-2
193 suppliers
$7.00/5g
330-12-1
259 suppliers
$15.00/10 g
Yield:330-12-1 98%
Reaction Conditions:
with sulfuric acid;water;acetic acid at 120;
Steps:
7.2
4-(Trifluoromethoxy)benzoic acid: To a solution of 4-(trifluoromethoxy)benzonitrile (4 g, 21.4 mmol) in acetic acid (12 mL) was added water (12 mL) and conc. H2SO4 (12 mL). The reaction mixture was heated overnight at 120° C. Water (100 mL) was added to the reaction mixture and the aqueous solution was extracted from EtOAc (3×100 mL). The combined organic solution was dried (Na2SO4) and concentrated in vacuo to afford the title compound (4.8 g, 98%) as a white solid.
References:
KALYPSYS, INC. US2007/270434, 2007, A1 Location in patent:Page/Page column 16-17
124-38-9
724 suppliers
$175.00/23402
407-14-7
398 suppliers
$5.00/1g
330-12-1
259 suppliers
$15.00/10 g
1736-74-9
210 suppliers
$14.00/5g
330-12-1
259 suppliers
$15.00/10 g
124-38-9
724 suppliers
$175.00/23402
169222-42-8
25 suppliers
$222.00/50ml
330-12-1
259 suppliers
$15.00/10 g
50824-05-0
337 suppliers
$10.00/5g
330-12-1
259 suppliers
$15.00/10 g