一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI)
402725-23-9

2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) synthesis

1synthesis methods
-

Yield:402725-23-9 25%

Reaction Conditions:

with hydroxylamine;acetic acid in water at 50; for 40 h;Sealed tube;Inert atmosphere;

Steps:

21 Example 21.EIDD-2159:

Example 21.EIDD-2159: A 2 N hydroxylamine (30.0 mL, 60.0 mmol) aqueous solution was made by adjusting a 50% w/w aq. NH2OH solution with glacial AcOH and then diluting with water to achieve the desired concentration. A sealable pressure vessel was charged with the above solution, L-cytidine (0.486 g, 2.0 mmol), and a stir bar. The vessel was sealed and the mixture was heated at 50°C for 40 h. The mixture was cooled to rt and concentrated by rotary evaporation. The crude reside was dissolved in water, and automated reverse phase flash chromatography (100 g column, gradient of 100% water to 100% MeCN) gave 300 mg of semipure material as a yellow flaky solid. The compound was taken up in MeOH and immobilized on Celite. Automated flash chromatography (12 g column, gradient of 10 to 25%) MeOH in DCM) gave -150 mg of a white flaky solid containing some occluded solvent. The residue was dissolved in water, frozen in a dry ice/acetone bath, and lyophilized to give the title compound (0.128 g, 0.494 mmol, 25% yield) as an off-white flocculent solid. Spectral analysis showed 90-95% purity; the impurity was unknown and inseparable by chromatography. 1H NMR (400 MHz, D20) δ 7.04 (d, J = 8.3 Hz, 1H), 5.83 (d, J = 5.7 Hz, 1H), 5.72 (d, J = 8.2 Hz, 1H), 4.27 (t, J = 5.5 Hz, 1H), 4.16 (t, J = 4.7 Hz, 1H), 4.03 (q, J = 3.9 Hz, 1H), 3.80 (dd, J= 12.9 Hz, 3.0 Hz, 1H), 3.72 (dd, J= 12.9 Hz, 4.2 Hz, 1H);13C NMR (100 MHz, D20) δ 151.1, 146.5, 131.2, 98.6, 87.8, 83.9, 72.4, 69.7, 60.9; HRMS calcd. forC9H14N3O6[M + H]+: 260.08771, found: 260.08734.

References:

WO2016/106050,2016,A1 Location in patent:Page/Page column 77; 78

2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) Related Search:

中阳县| 临沂市| 宁波市| 古丈县| 陆良县| 丹巴县| 尉氏县| 清徐县| 德安县| 云龙县| 广西| 永嘉县| 常德市| 北海市| 遂昌县| 大邑县| 勐海县| 嘉兴市| 永仁县| 遂宁市| 县级市| 德格县| 镇原县| 黔东| 西华县| 富锦市| 东乌| 布尔津县| 祁阳县| 通海县| 嘉善县| 洛南县| 吉安县| 女性| 万源市| 东辽县| 门源| 班玛县| 泉州市| 武山县| 德化县|