ChemicalBook CAS DataBase List N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine synthesis

13synthesis methods

Product Name:N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
CAS Number:444731-75-3
Molecular formula:C14H14ClN5
Molecular Weight:287.75

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

3934-20-1 Synthesis

3934-20-1
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444731-75-3
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Yield:444731-75-3 97%

Reaction Conditions:

with Sodium hydrogenocarbonate in water monomer;N,N-dimethyl-formamide at 85; for 3 h;

Steps:

2 Example 2 Preparation of N-(2-chloropyrimidin-4-yl)-.N,2,3-trimethyl-2H-indazol-6-amine (Formula 4)

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N,N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water and then dried to get title compound as off-white/beige powder (Yield: 97%; LC-purity: 98.5%).

References:

WO2021/162647,2021,A1 Location in patent:Page/Page column 11

444731-74-2 Synthesis