DIETHYL 5-AMINO-3-METHYL-2,4-THIOPHENEDICARBOXYLATE synthesis
- Product Name:DIETHYL 5-AMINO-3-METHYL-2,4-THIOPHENEDICARBOXYLATE
- CAS Number:4815-30-9
- Molecular formula:C11H15NO4S
- Molecular Weight:257.31
141-97-9
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$5.00/25g
105-56-6
458 suppliers
$10.00/5ml
4815-30-9
205 suppliers
$13.00/5g
Yield: 84%
Reaction Conditions:
Stage #1:ethyl acetoacetate;ethyl 2-cyanoacetate with ammonium acetate in tolueneReflux;Green chemistry;Gewald Aminoheterocycles Synthesis;
Stage #2: with sulfur at 60; for 4 h;Ionic liquid;Green chemistry;Gewald Aminoheterocycles Synthesis;
Steps:
4-Aryl-2-aminothiophenes (5a-g) and 4-Alkoxy-2-aminothiophenes(8a-h)
General procedure: A mixture of 2-(1-ethoxyethylidene)malononitrile[27] (7b, 272 mg, 2 mmol),sulfur (64 mg, 2 mmol), and basic ionic liquid (bmIm)OH (380 mg, 2.4 mmol) was allowed to stir at 60°C for 4 h. The reaction mixture was cooled to room temperature and washed with diethyl ether or ethyl acetate (330 mL), and organic layers were concentrated to 1/4 of the volume and kept in a refrigerator. The precipitate that formed was filtered and dried.
References:
Kaki, Venkata Rao;Akkinepalli, Raghuram Rao;Deb, Pran Kishore;Pichika, Mallikarjuna Rao [Synthetic Communications,2015,vol. 45,# 1,p. 119 - 126]
15933-07-0
133 suppliers
$8.00/1g
105-56-6
458 suppliers
$10.00/5ml
4815-30-9
205 suppliers
$13.00/5g