5,6-difluoro-indoline-2,3-dione synthesis
- Product Name:5,6-difluoro-indoline-2,3-dione
- CAS Number:774-47-0
- Molecular formula:C8H3F2NO2
- Molecular Weight:183.11
370-55-8
774-47-0
GENERAL PROCEDURE: To a stirred 18.1 M aqueous sulfuric acid solution (0.68 mL/mmol), isonitrosoacetanilide (1 equiv.) was added in batches at 60 °C. The reaction mixture was placed in a heating block and stirred at an internal temperature of 80 °C for 30 min, followed by cooling to room temperature. The reaction solution was slowly poured into a saturated ice-water mixture (5 mL/g) and stirred at room temperature for 10 minutes. The resulting solid was collected by filtration, dried and purified according to standard methods.
370-55-8
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774-47-0
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Yield: 86%
Reaction Conditions:
with sulfuric acid in water at 60 - 80; for 0.5 h;Inert atmosphere;regioselective reaction;
Steps:
General Procedure 1: Isatin formation
General procedure: To a stirred solution of aqueous 18.1 M sulfuric acid (0.68 mL/mmol) at 60 °C was added the isonitrosoacetanilide (1 equiv.) portionwise. The reaction mixture was stirred in a heating block for 30 minutes at an internal temperature of 80 °C, then the mixture was cooled to room temperature. The solution was added slowly to a saturated water/ice mixture (5 mL/g)and stirred for 10 minutes at room temperature. The resultant solid was filtered, dried and purified as specified
References:
Lindsay-Scott, Peter J.;Barlow, Helen [Synlett,2016,vol. 27,# 10,art. no. ST-2016-D0029-L,p. 1516 - 1520] Location in patent:supporting information
507-40-4
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5466-06-8
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3863-11-4
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169037-22-3
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774-47-0
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774-47-0
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302-17-0
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3863-11-4
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774-47-0
78 suppliers
$8.00/250mg