5-Chloro-2-fluoronitrobenzene synthesis
- Product Name:5-Chloro-2-fluoronitrobenzene
- CAS Number:345-18-6
- Molecular formula:C6H3ClFNO2
- Molecular Weight:175.54
89-61-2
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345-18-6
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Yield:345-18-6 77.2%
Reaction Conditions:
with potassium fluoride;bis(tricyclohexylphosphine)nickel(II) dichloride;tetrabutyl ammonium fluoride in N,N-dimethyl-formamide at 150; for 8 h;Inert atmosphere;
Steps:
7 Synthesis of 5-chloro-2-fluoro-nitrobenzene
Weigh 0.52g (0.75mmol) of dichloro-di-dicyclohexylphosphine nickel into a 250mL three-necked flask, add 2.88g (15.0mmol) of 2,5-dichloro-nitrobenzene,And add 40mL deoxygenated DMF, start stirring under nitrogen protection,Dissolve the material.Then 1.74g (30mmol) of potassium fluoride and 0.24g (0.75mmol) of tetrabutylammonium fluoride were added. Start stirring,Heat to a slight boiling (150) under the protection of nitrogen, keep it at this temperature for 8 hours and then cool to room temperature naturally.Filter solids,Liquid vacuum distillation,Recover the solvent DMF,The product 5-chloro-2-fluoro-nitrobenzene 2.03g,The yield was 77.2%.
References:
Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.;Jiang Peng;Wang Qiang CN111848695, 2020, A Location in patent:Paragraph 0045-0047
1493-27-2
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345-18-6
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371-40-4
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345-18-6
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352-33-0
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345-18-6
204 suppliers
$7.00/5g