一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-Fluoroaniline
371-40-4

4-Fluoroaniline synthesis

11synthesis methods
The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.
-

Yield:371-40-4 100%

Reaction Conditions:

with 10% Pd/C;hydrogen in methanol at 20; for 3 h;

Steps:

2 4.2.2. 4-Fluoroaniline (4a)

To a solution of 4-fluoro-1-nitrobenzene (3a, 212 mL, 2.00 mmol)in MeOH (10 mL) was added 10% Pd/C (21 mg, 0.020 mmol). Thereaction mixture was stirred and bubbled with H2 at room temperaturefor 3 h. The solids were filtered off and washed with DCM(25 mL). The filtrate and DCM washing were combined andconcentrated under reduced pressure to give 4a as a clear yellow oil(222 mg, 100%).

References:

Teo, Theodosia;Yang, Yuchao;Yu, Mingfeng;Basnet, Sunita K.C.;Gillam, Todd;Hou, Jinqiang;Schmid, Raffaella M.;Kumarasiri, Malika;Diab, Sarah;Albrecht, Hugo;Sykes, Matthew J.;Wang, Shudong [European Journal of Medicinal Chemistry,2015,vol. 103,p. 539 - 550]

4-Fluoroaniline Related Search:

肥西县| 大同市| 特克斯县| 勃利县| 施秉县| 镇雄县| 施秉县| 陆丰市| 绵阳市| 青州市| 桐城市| 余姚市| 图木舒克市| 定结县| 江津市| 宜丰县| 调兵山市| 临泉县| 麟游县| 无为县| 惠水县| 沁源县| 琼海市| 大英县| 东海县| 高青县| 高唐县| 长宁县| 达州市| 东兴市| 星座| 台南县| 永宁县| 镇康县| 定边县| 兴义市| 光山县| 永嘉县| 波密县| 珠海市| 吉林省|