4'-Aminoacetanilide synthesis
- Product Name:4'-Aminoacetanilide
- CAS Number:122-80-5
- Molecular formula:C8H10N2O
- Molecular Weight:150.18
64-19-7
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141-78-6
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$20.50/250ml
106-50-3
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122-80-5
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$36.00/25g
Yield:122-80-5 98.6%
Reaction Conditions:
with 1,4-diaza-bicyclo[2.2.2]octane at 65 - 90; for 6 h;Inert atmosphere;Time;
Steps:
1-3 Preparation of p-aminoacetanilide:
1) Add 120.00g of ethyl acetate, 32.00g of p-phenylenediamine, and 0.26g of triethylenediamine to a 250ml four-necked flask equipped with a stirring, condensation and heating system, and mix well to obtain a mixed solution; 2) Under the protection of nitrogen, heat the mixed solution to 65-90 °C, add 10.00g of acetic acid dropwise, after the addition, react at 78-82°C for 6 hours; 3) After the reaction, the temperature is lowered to 15-25 °C, and the filter cake is filtered after standing for 6.5 hours. After the filter cake is fully washed with n-butanol and dried at 80 °C in vacuum for 6 hours, 31.84g of white crystals of p-aminoacetanilide can be obtained.It can be seen from Figure 1 that the purity of p-aminoacetanilide was 99.1% by liquid phase detection, and the yield based on the weight of p-phenylenediamine was 98.6%.
References:
Zhengzhou Kekuang Biological Technology Co., Ltd.;Niu Guofeng;Liu Shuhui;Li Meixiang;Liu Bo CN112225670, 2021, A Location in patent:Paragraph 0028-0045
![N-[4-(1-Hydroxyethyl)phenyl]acetamide](/CAS/GIF/16375-92-1.gif)
16375-92-1
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122-80-5
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106-50-3
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507-09-5
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122-80-5
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104-04-1
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122-80-5
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108-24-7
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106-50-3
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122-80-5
267 suppliers
$36.00/25g